Advances in Cancer Research, Vol. 108 - download pdf or read online

By George F. Vande Woude (ed.), George Klein (ed.)

ISBN-10: 012380888X

ISBN-13: 9780123808882

Presents worthwhile details at the interesting and fast-moving box of melanoma research. Outstanding and unique stories are offered on quite a few themes.

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The results showed that baseline viral load influenced HBV genotype-specific HCC risks and persistence of high viral load (! 39 log10 copies/mL) could predict HCC development. 0369) and longitudinal ALTelevation (defined as ALTabnormality in ! 0005) were positively correlated with longer duration of persistence for high viral load. 34), high viral load detected at ! 9% of HCC patients, respectively. 39 log10 copies/mL may be associated with normalization of ALT levels and decreased risk of HCC development.

37 Recent Advances in the Research of Hepatitis B 1613 1849 Core promoter Upstream regulatory region Basal core promoter 1742 Enhancer II 1627 1774 Box a 1644 Box b 1666 1701 1713 1653 GTCTTACATAAGACGACTCT 1752/1753 1762/1764/1766 GATTAGGTTAAAGGTCTTT C V I T HB-X protein L H K H94Y R T L K A G V I127N/S/T K130M V131I Fig. 6 Commonly encountered mutations in core promoter region of hepatitis B virus genome. Table III Combined Risk of Hepatocellular Carcinoma Associated with Serum HBV DNA Level and Basal Core Promoter A1762T/G1764A Mutation Age (per year) Gender (male) Genotype (C) 5 Viral load !

On the basis of these emerging data, it is recommended that HBV carriers should be screened and monitored to identify those who have a higher risk of liver disease progression and require antiviral treatments. Regarding the molecular carcinogenesis of HCC development, despite some progress in the research of cell biology of HCC in the past decade, aberrant pathways involved in maintaining HCC phenotypes have not been completely elucidated yet. In the future, through comprehensive and integrated approaches to analyze the genomes of human HCC, novel target genes or pathways critically involved in hepatocarcinogenesis may hopefully be identified.

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Advances in Cancer Research, Vol. 108 by George F. Vande Woude (ed.), George Klein (ed.)

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