Download e-book for iPad: Amphetamines - A Medical Dictionary, Bibliography, and by Health Publica Icon Health Publications

By Health Publica Icon Health Publications

ISBN-10: 0597837309

ISBN-13: 9780597837302

This can be a 3-in-1 reference ebook. It provides an entire clinical dictionary masking thousands of phrases and expressions on the subject of amphetamines. It additionally offers large lists of bibliographic citations. ultimately, it offers info to clients on how you can replace their wisdom utilizing numerous web assets. The e-book is designed for physicians, clinical scholars getting ready for Board examinations, clinical researchers, and sufferers who are looking to familiarize yourself with study devoted to amphetamines. in the event that your time is effective, this e-book is for you. First, you won't waste time looking the net whereas lacking loads of appropriate details. moment, the ebook additionally saves you time indexing and defining entries. ultimately, you won't waste money and time printing hundreds of thousands of websites.

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In vitro testing will include determination of IC50 and Ki values for all piperidines synthesized and thcir DAT/5-HT selectivity values. In addition, the ability of the new compounds to prevent induced monoamine release following methamphetamine application in vitro will be determined. Finally, in vivo behavioral place preference studies will be performed with the compounds to assess their reinforcing properties. The long-range 28 Amphetamines goal of the project is to submit compounds that have appropriate profiles and lack abuse potential to the NIDA Division of Treatment Research and Development for further consideration as potential therapeutic agents for cocaine addiction.

Elegans dopamine transporter DAT-1) shows a 45% homology to the human transporter, with a sensitivity to amphetamines, cocaine, and other biogenic amine transporter antagonists. In my proposal, I build on recent studies by our laboratory on DAT-1 to: 1) determine the expression level and localization of DAT-1, 2) characterize the interactions of the C. 22) with DAT-1 and, 3) identify novel proteins that interact with the C. elegans dopamine transporter. These studies will increase our understanding of intrinsic modulatory influences controlling DA signaling in vivo and in disease states.

Associate Professor; Neurology; Johns Hopkins University 3400 N Charles St Baltimore, Md 21218 Timing: Fiscal Year 2001; Project Start 01-MAR-1994; Project End 29-FEB-2004 Studies 31 Summary: This is a competing renewal application for an Independent Scientist Award (K02) that is intended to enable the applicant to continue engaging in intensive research for an additional five year period. Research in the appplicant's laboratory focuses on substituted amphetamine derivatives (MDMA, methamphetamine, fenfluramine) and their propensity to selectively damage brain serotonin and/or dopamine neurons in animals and, possibly, humans.

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Amphetamines - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References by Health Publica Icon Health Publications


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