By Lorenzo Cerroni
Epidermis lymphomas are really infrequent. they could come up within the pores and skin itself and as a derivative of HIV an infection, or might come up in other places due to Hodgkin's ailment, B mobilephone lymphomas or leukaemia. regardless of the reason, they could simply be missed as psoriasis or dermatitis.
Diagnosis of pores and skin lymphoma is tough and making the incorrect analysis can turn out deadly. for this reason, these in education in dermatology and pathology must have an excellent figuring out of the scientific displays and the pathological correlates of this difficult ailment.
An Illustrated consultant to epidermis Lymphoma is a gorgeous full-colour illustrated textual content and atlas that mixes pathology with medical positive aspects and remedy. This moment version comprises the most recent type platforms for cutaneous lymphomas in addition to fresh chapters and an increased part on therapy.
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Extra resources for An Illustrated Guide to Skin Lymphoma
Scarisbrick JJ, Child FJ, Clift A et al. A trial of fludarabine and cyclophosphamide combination chemotherapy in the treatment of advanced refractory primary cutaneous T-cell lymphoma. Br J Dermatol 2001; 144: 1010 –5. Zinzani PL, Baliva G, Magagnoli M et al. Gemcitabine treatment in pretreated cutaneous T-cell lymphoma: experience in 44 patients. J Clin Oncol 2000; 18: 2603 – 6. Akpek G, Koh HK, Bogen S, O’Hara C, Foss FM. Chemotherapy with etoposide, vincristine, doxorubicin, bolus cyclophosphamide, and oral prednisone in patients with refractory cutaneous T-cell lymphoma.
Arch Dermatol 1996; 132: 567–72. Cerroni L, Fink-Puches R, Bäck B, Kerl H. Follicular mucinosis: a critical reappraisal of clinicopathologic features and association with mycosis fungoides and Sézary syndrome. Arch Dermatol 2002; 138: 182–9. Flaig MJ, Cerroni L, Schuhmann K et al. Follicular mycosis fungoides: a histopathologic analysis of nine cases. J Cutan Pathol 2001; 28: 525 –30. van Doorn R, Scheffer E, Willemze R. Follicular mycosis fungoides, a distinct disease entity with or without associated follicular mucinosis.
One case with a complex p53 gene mutation has been observed in a Chernobyl survivor, suggesting a possible relationship with environmental factors . The association with viral infections or previous long-standing dermatoses is unclear [14–16]. Much information on the neoplastic cells has been gathered by studies on tissue samples and cell lines. In most cases, so-called Sézary cells express a predominantly helper T-cell type 2 (Th2) cytokine profile, characterized by expression of interleukin 4 (IL-4), IL-5 and IL-10.
An Illustrated Guide to Skin Lymphoma by Lorenzo Cerroni