Download e-book for iPad: Analytical and Practical Aspects of Drug Testing in Hair by Pascal Kintz

By Pascal Kintz

ISBN-10: 0849364507

ISBN-13: 9780849364501

Many advances were made because the e-book of Drug trying out in Hair. The mid-1990s witnessed the growth in hashish detection whereas the past due Nineties eager about benzodiazepines detection and the functions in doping keep watch over. in additional fresh years, toxicologists founded at the detection in hair of a unmarried publicity and the similar functions in drug-facilitated crimes. featuring those subject matters in addition to the newest findings from the foreign neighborhood, Analytical and sensible elements of Drug trying out in Hair experiences all new advancements, the validation of analytical approaches, and the translation of knowledge. Written via famous, overseas authors, this complete reference offers sensible insurance of the easiest drug checking out innovations and examines the medicine themselves. the various functions mentioned contain doping, drug-facilitated crime investigating, office checking out, and the granting of drivers' licenses. The authors describe particular medications, resembling opiates, cocaine, and hashish, and speak about different checking out equipment for them. The booklet additionally covers postmortem toxicology, pitfalls created by means of passive publicity, and trying out for metals, together with inductively coupled plasma spectrometry (ICP-MS), hair multielementary research, and the hot speciation analysis.A entire, up to date source that explains a variety of drug trying out thoughts, Analytical and sensible facets of Drug checking out in Hair presents valuable details for toxicologists, forensic scientists, activities drugs experts, and pathologists.

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Extra info for Analytical and Practical Aspects of Drug Testing in Hair (International Forensic Science and Investigation)

Sample text

On pathways for small molecules into and out of human hair fibers, J. , 41, 121–125, 1996. 22. , Influence of pigmentation on the codeine content of hair fibers in guinea pigs, J. , 42, 1095–1098, 1997. 23. , A comparison of 3H-cocaine binding on melanin granules and human hair in vitro, Int. J. , 110, 55–62, 1997. fm Page 21 Wednesday, August 2, 2006 2:11 PM Drug Incorporation into Hair 21 24. , Incorporation and retention of radiolabeled S-(+)-and R-(-)-methamphetamine and S(+)- and R(-)-N-(n-butyl)-amphetamine in mouse hair after systemic administration, Drug Metab.

After the hair emerges from the scalp, these drugs form bands that are in direct proportion to the concentrations present when the hair was formed. The entrapped drugs are protected by the hair matrix so that they cannot be removed or changed by the external environment. Because hair grows at a relatively constant rate, this model predicts that hair analysis would provide a history of drug consumption in both time and amount. There is little or no direct evidence in support of this hypothetical construct of inaccessible regions in hair.

Fm Page 23 Wednesday, August 2, 2006 2:11 PM Drug Incorporation into Hair 23 64. J. , Amphetamine adducts of melanin intermediates demonstrated by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, Chem. Res. , 14, 1339–1344, 2001. 65. , Nicotine and cotinine accumulation in pigmented and unpigmented rat hair, Drug Metab. Dispos. Biol. , 23, 143–148, 1995. 66. J. , The effect of hair color on the incorporation of methadone into hair in the rat, J. Anal. , 20, 121–123, 1996.

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Analytical and Practical Aspects of Drug Testing in Hair (International Forensic Science and Investigation) by Pascal Kintz


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